WebDrug distribution refers to the postabsorptive transfer of drugs from one location in the body to another. The distribution process has been modeled from the bottom up in … WebSep 27, 2024 · Redistribution • Highly lipid-soluble drugs get initially distributed to organs with high blood flow ( brain, heart, kidney) & later into bulky less vascular tissues (muscle, fat) • So plasma concentration falls and the drug is withdrawn from these sites • If the site of action of drug is one of highly perfused organs, redistribution may ...
Drug Termination of Action Anesthesiology Core Review: Part …
WebJun 13, 2016 · The drugs are eliminated by hepatic metabolism, with serum elimination half-lives of 1–50 hours. The duration of CNS effects is determined by the rate of drug redistribution from the brain to peripheral tissues. Active metabolites further extend the duration of effect of diazepam. WebThe animals infused intravenously after death demonstrated high drug levels in blood samples from central vessels, heart, lungs as well as cerebrospinal fluid and vitreous humour, implying that the presence of a lethal concentration of a drug in just one sample of heart blood can prove worthless in a case where agonal drug infusion may have occurred. paradise cove beach freeport bahamas
Drug distribution - SlideShare
WebRedistribution is the mechanism responsible for termination of action of thiopental (pentothal) or propofol (Diprivan), anesthetic inducing agents. Benet, Leslie Z, … WebPostmortem drug redistribution refers to the processes by which the movement of drugs and other chemical poisons between tissues, organs, and body fluids takes place after death. This phenomenon is well recognised, and was first reported 25 years ago. 1 … Web14 1) nursing homes to recycle prescription drugs that are unused, sealed, and dated; 2) physician 15 offices and clinics to donate prescription drugs that are unused, sealed, … paradise cove carolina beach nc