Cisplatin induced aki

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August undefined, 2024

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … WebNational Center for Biotechnology Information

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

WebSep 2, 2024 · Melatonin alleviates renal dysfunction in sepsis-induced acute kidney injury. 8-week-old mice were treated with melatonin (25 μg/ml) dissolved in drinking water for 14 days. ... Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury in Rats via Induction of Anti-Aging Protein, Klotho. Food Chem. Toxicol. 129, 201–210. … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … how to login hostinger email

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WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebFeb 1, 2016 · Cisplatin, a commonly used cancer chemotherapeutic, has a dose-limiting side effect of nephrotoxicity. Approximately 30% of patients administered cisplatin suffer from … WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … how to login hostinger mail in gmail

Frontiers Protective Effect of Mannitol on Cisplatin-Induced ...

PSTPIP2 inhibits cisplatin-induced acute kidney injury by …

Websuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … how to log in hello freshWebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who are receiving cisplatin ... how to login herobrine.org

"WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … " - Cisplatin induced aki

Cisplatin induced aki

Emerging Role of Ferroptosis in Acute Kidney Injury - Hindawi

WebAug 6, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. WebDec 21, 2024 · The clinical use of cisplatin has been hampered by its dose-dependent side effects, e.g., nephrotoxicity, and the precise mechanism(s) related to such a cisplatin-induced acute kidney injury (AKI) remain elusive, despite many investigations that were devoted to this subject matter over a period of decades.

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WebJan 3, 2024 · Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and management; Crystal-induced acute kidney injury; Dosing of anticancer agents in adults; Drug reaction with eosinophilia and systemic … WebJan 18, 2024 · Background Early detection and prediction of cisplatin-induced acute kidney injury (Cis-AKI) are essential for the management of patients on chemotherapy with cisplatin. This study aimed to evaluate the performance of a prediction model for Cis-AKI. Methods Japanese patients, who received cisplatin as the first-line chemotherapy at …

WebMar 29, 2024 · Cisplatin-induced acute kidney injury effects on the renin angiotensin system. A large focus has been on inhibition or genetic deletion of AT1 and AT2 … WebCisplatin-induced AKI typically occurs 5–7 days after therapy, whereas dialysis-requiring AKI is uncommon in the absence of concomitant nephrotoxic exposures. AKI typically resolves within a few weeks, but progressive CKD …

WebDec 12, 2024 · Cisplatin can induce AKI through ischemic damage, by reducing the blood flow in the medulla of the kidneys leading to tubular cell injury. Vasoconstriction due to … WebAug 6, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often …

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular uptake and efflux, apoptosis, vascular injury, oxidative and endoplasmic reticulum stress, and inflammation …

WebDec 12, 2024 · Cisplatin (CP) is an effective chemotherapeutic agent widely used in the treatment of various solid tumours. However, CP nephrotoxicity is an important limitation … how to login hostinger mailWebOther pathogenic factors such as FA, oxalate, cisplatin, and gentamicin can also promote the occurrence of Fenton-like chemistry, induce ferroptosis, and lead to AKI. The Fenton-like chemistry can be inhibited by intracellular GPX4, a … how to log in hotmail accountWebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … how to login hostinger cpanelWebThe results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under … joss and main white shower curtainWebPrevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis Prevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis Authors joss and main white console tableWebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … joss and main wine rackWebMay 18, 2024 · The incidence of cisplatin-induced AKI in elderly patients was significantly higher than that of cisplatin-induced renal toxicity partly because three of the included studies defined AKI as a 25% increase in baseline creatinine, one as 20% reduction in Ccr, and two as a 0.3–0.4 mg/dl increase in baseline creatinine, which is more sensitive than … how to login hotstar in laptop